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Role of UHRF1 in liver development, regeneration and carcinogenesis.

NIDDK-RO1

Recent studies suggest a role of UHRF1 in liver regeneration (Sadler KC et al. PNAS 2007), even though the mechanism of action by which this molecular regulates this process remains unknown. Our aim is to determine whether UHRF1 can also be implicated in any step of human hepatocarcinogenesis using genomic data from human samples and engineered animal models (zebrafish).

Translational research in liver cancer

Liver Cancer Translational Research Laboratory

BCLC-IDIBAPS, Liver Unit, Hospital Clínic · Esther Koplowitz Center, 3rd Floor
Rosselló 153 · 08036 Barcelona · Tel: +34 93 227 9155

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