Current analysis includes evaluation of Notch, IGFR, FGFR and WNT-ßcatenin. Activation of these cascades has been found in a subset of HCC patients. We are currently evaluating their implication in tumor progression and the antitumoral activity following their selective blockade. In parallel, we are evaluating the oncogenic role of some of their components in transgenic models.
Translational research in liver cancer